主要論文紹介

2025年

  • Kita M, Morita S, Ariyasu H, Tsuji T, Uraki S, Takeshima K, Iwakura H, Matsuoka TA.
    Severe obesity with hypo-leptinemia.
    Endocr J. 2025 Mar 22. doi: 10.1507/endocrj.EJ24-0568. Epub ahead of print.
    DOI PubMed: 40128964
  • Ueda Y, Iwakura H, Ensho T, Bando-Shimizu M, Doi A, Matsutani N, Morita S, Inaba H, Ariyasu H, Fukuda N, Hayata K, Ojima T, Nishi M, Matsuoka TA, Yamaue H, Akamizu T.
    Tryptophan-sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin-producing cells.
    FEBS Open Bio. 2025 May;15(5):763-772. doi: 10.1002/2211-5463.13973. Epub 2025 Jan 30.
    DOI PubMed: 39888273
  • Taguchi A, Uraki S, Akiyama M, Nagao Y, Watanabe K, Mizukami Y, Ohta Y.
    Unexplained Hypokalemia in a Patient With Obesity Harboring an Armadillo Repeat-Containing 5 (ARMC5) Gene Variant: A Case Report.
    Cureus. 2025 Feb 19;17(2):e79326. doi: 10.7759/cureus.79326.
    DOI PubMed: 40130155
  • Morita S, Shimajiri Y, Matsuoka Y, Kadoya Y, Yamada S, Matsuoka TA, Sanke T.
    Exploring genetic risk factors for β-cell deterioration in type 2 diabetes mellitus: Insights from longitudinal C-peptide analysis.
    Diabetes Res Clin Pract. 2025 Apr;222:112049. doi: 10.1016/j.diabres.2025.112049. Epub 2025 Feb 17.
    DOI PubMed: 39971135
  • Nakano Y, Takeshima K, Furukawa Y, Morita S, Sakata M, Matsuoka TA.
    Concomitant Exacerbation of Graves Orbitopathy and Double-Seronegative Myasthenia Gravis after SARS-CoV-2 Infection.
    JCEM Case Rep. 2025 Jan 29;3(2):luaf019. doi: 10.1210/jcemcr/luaf019.
    DOI PubMed: 39882352
  • Nakao T, Takeshima K, Morita S, Yamauchi I, Koyasu S, Matsuoka TA.
    Tumor-Induced Osteomalacia Localized by Systemic Venous Sampling and 68Ga-DOTATOC Positron Emission Tomography.
    JCEM Case Rep. 2025 Jan 24;3(2):luaf012. doi: 10.1210/jcemcr/luaf012.
    DOI PubMed: 39866919

2024年

  • Sasaki I, Fukuda-Ohta Y, Nakai C, Wakaki-Nishiyama N, Okamoto C, Okuzaki D, Morita S, Kaji S, Furuta Y, Hemmi H, Kato T, Yamamoto A, Tosuji E, Saitoh SI, Tanaka T, Hoshino K, Fukuda S, Miyake K, Kuroda E, Ishii KJ, Iwawaki T, Furukawa K, Kaisho T.
    A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages.
    Cell Rep. 2024 Apr 23;43(4):113981. doi: 10.1016/j.celrep.2024.113981. Epub 2024 Mar 24.
    DOI PubMed: 38520688
  • Tabata S, Yamashita Y, Inai Y, Morita S, Kosako H, Takagi T, Shide K, Manabe S, Matsuoka TA, Shimoda K, Sonoki T, Ihara Y, Tamura S.
    C-Mannosyl tryptophan is a novel biomarker for thrombocytosis of myeloproliferative neoplasms.
    Sci Rep. 2024 Aug 14;14(1):18858. doi: 10.1038/s41598-024-69496-z.
    DOI PubMed: 39143127
  • Kurimoto C, Furukawa Y, Akamizu T, Doi A, Takeshima K, Morita S, Iwakura H, Ariyasu H, Furuta H, Nishi M, Matsuoka TA.
    Generation of a mouse model of thyroid storm and preliminary investigation of the therapeutic effects of ghrelin.
    BMC Endocr Disord. 2024 Aug 12;24(1):150. doi: 10.1186/s12902-024-01680-8.
    DOI PubMed: 39135012
  • Furukawa Y, Tanaka K, Isozaki O, Suzuki A, Iburi T, Tsuboi K, Iguchi M, Kanamoto N, Minamitani K, Wakino S, Satoh T, Teramukai S, Kimura E, Miyake Y, Akamizu T.
    Prospective Multicenter Registry-Based Study on Thyroid Storm: The Guidelines for Management From Japan Are Useful.
    J Clin Endocrinol Metab. 2024 Dec 18;110(1):e87-e96. doi: 10.1210/clinem/dgae124.
    DOI PubMed: 38454797
  • Morita S, Uraki S, Ariyasu H, Tsuji T, Doi A, Furuta H, Yamoto T, Nakao N, Akamizu T, Matsuoka TA.
    Profiling of Unfolded Protein Response Markers and Effect of IRE1α-specific Inhibitor in Pituitary Neuroendocrine Tumor.
    Endocrinology. 2024 Feb 20;165(4):bqae008. doi: 10.1210/endocr/bqae008.
    DOI PubMed: 38289718
  • Shikama M, Suga S, Tajima T, Kozawa J, Maeda N, Otsuki M, Matsuoka TA, Shimomura I, Ohno Y.
    Association Between Maximum Lifetime Body Mass Index and Nailfold Capillary Changes in Patients With Type 2 Diabetes Mellitus.
    Cureus. 2024 Dec 9;16(12):e75411. doi: 10.7759/cureus.75411.
    DOI PubMed: 39781172
  • Ishibashi T, Nishi N, Kita M, Uenoyama S, Nakao T, Takeshima K, Furukawa Y, Morita S, Furuta H, Sanke T, Matsuoka TA.
    Impact of angiotensin receptor neprilysin inhibitor on serum C-peptide levels in patients with type 2 diabetes.
    Diabetol Int. 2024 Oct 18;16(1):194-198. doi: 10.1007/s13340-024-00761-2.
    DOI PubMed: 39877457
  • Ibe M, Tamura S, Kosako H, Yamashita Y, Ishii M, Tanaka M, Mishima H, Kinoshita A, Iwabuchi S, Morita S, Yoshiura KI, Hashimoto S, Nakao N, Inoue S.
    Familial schwannomatosis carrying LZTR1 variant p.R340X with brain tumor: A case report.
    Mol Genet Metab Rep. 2024 Jun 18;40:101107. doi: 10.1016/j.ymgmr.2024.101107.
    DOI PubMed: 38983105

2023年

  • Iwakura H, Takagi T, Inaba H, Doi A, Ueda Y, Uraki S, Takeshima K, Furukawa Y, Ishibashi T, Morita S, Matsuno S, Nishi M, Furuta H, Matsuoka TA, Akamizu T.
    Thyroid function, glycemic control, and diabetic nephropathy in patients with type 2 diabetes over 24 months: prospective observational study.
    BMC Endocr Disord. 2023 Jul 10;23(1):146. doi: 10.1186/s12902-023-01393-4.
    DOI PubMed: 37430240
  • Morita S, Takagi T, Inaba H, Furukawa Y, Kishimoto S, Uraki S, Shimo N, Takeshima K, Uraki S, Doi K, Imagawa M, Kokawa M, Konami T, Hara H, Hara Y, Sone E, Furuta H, Nishi M, Doi A, Tamura S, Matsuoka TA.
    Effect of SARS-CoV-2 BNT162b2 mRNA vaccine on thyroid autoimmunity: A twelve-month follow-up study.
    Front Endocrinol (Lausanne). 2023 Jan 27;14:1058007. doi: 10.3389/fendo.2023.1058007. Erratum in: Front Endocrinol (Lausanne). 2023 Jul 24;14:1257424. doi: 10.3389/fendo.2023.1257424.
    DOI PubMed: 36777341
  • Tsuyama T, Sato Y, Yoshizawa T, Matsuoka T, Yamagata K.
    Hypoxia causes pancreatic β-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40.
    EMBO Rep. 2023 Aug 3;24(8):e56227. doi: 10.15252/embr.202256227. Epub 2023 Jun 21.
    DOI PubMed: 37341148
  • Inaba H, Kaido Y, Kosugi D, Asai Y, Ogino S, Nakano S, Ito S, Hirobata T, Ono K, Minaga K, Morita S, Inoue G.
    Pheochromocytoma Multisystem Crisis Complicated by Severe Acute Pancreatitis.
    Intern Med. 2023 Jul 1;62(13):1957-1963. doi: 10.2169/internalmedicine.0742-22. Epub 2022 Nov 23.
    DOI PubMed: 36418097

2022年

  • Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Matsuoka TA, Kaku K.
    Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus.
    Biomedicines. 2022 Mar 31;10(4):818. doi: 10.3390/biomedicines10040818.
    DOI PubMed: 35453568
  • Hidaka N, Koga M, Kimura S, Hoshino Y, Kato H, Kinoshita Y, Makita N, Nangaku M, Horiguchi K, Furukawa Y, Ohnaka K, Inagaki K, Nakagawa A, Suzuki A, Takeuchi Y, Fukumoto S, Nakatani F, Ito N.
    Clinical Challenges in Diagnosis, Tumor Localization and Treatment of Tumor-Induced Osteomalacia: Outcome of a Retrospective Surveillance.
    J Bone Miner Res. 2022 Aug;37(8):1479-1488. doi: 10.1002/jbmr.4620. Epub 2022 Jul 1.
    DOI PubMed: 35690913
  • Morita S, Tsuji T, Kishimoto S, Uraki S, Takeshima K, Iwakura H, Furuta H, Nishi M, Inaba H, Matsuoka TA.
    Isolated ACTH deficiency following immunization with the BNT162b2 SARS-CoV-2 vaccine: a case report.
    BMC Endocr Disord. 2022 Jul 19;22(1):185. doi: 10.1186/s12902-022-01095-3.
    DOI PubMed: 35854260
  • Fukuda N, Ojima T, Hayata K, Katsuda M, Kitadani J, Takeuchi A, Goda T, Ueda Y, Iwakura H, Nishi M, Yamaue H.
    Laparoscopic sleeve gastrectomy for morbid obesity improves gut microbiota balance, increases colonic mucosal-associated invariant T cells and decreases circulating regulatory T cells.
    Surg Endosc. 2022 Oct;36(10):7312-7324. doi: 10.1007/s00464-022-09122-z. Epub 2022 Feb 19.
    DOI PubMed: 35182212
  • Okita T, Kita S, Fukuda S, Fukuoka K, Kawada-Horitani E, Iioka M, Nakamura Y, Fujishima Y, Nishizawa H, Kawamori D, Matsuoka TA, Norikazu M, Shimomura I.
    Soluble T-cadherin promotes pancreatic β-cell proliferation by upregulating Notch signaling.
    iScience. 2022 Nov 7;25(11):105404. doi: 10.1016/j.isci.2022.105404.
    DOI PubMed: 36439986
  • Kosako H, Yamashita Y, Morita S, Iwabuchi S, Hashimoto S, Matsuoka TA, Sonoki T, Tamura S.
    Allosteric Inhibition of c-Abl to Induce Unfolded Protein Response and Cell Death in Multiple Myeloma.
    Int J Mol Sci. 2022 Dec 18;23(24):16162. doi: 10.3390/ijms232416162.
    DOI PubMed: 36555805
  • Inaba H, Kaido Y, Ito S, Hirobata T, Inoue G, Sugita T, Yamamoto Y, Jinnin M, Kimura H, Kobayashi T, Iwama S, Arima H, Matsuoka T.
    Human Leukocyte Antigens and Biomarkers in Type 1 Diabetes Mellitus Induced by Immune-Checkpoint Inhibitors.
    Endocrinol Metab (Seoul). 2022 Feb;37(1):84-95. doi: 10.3803/EnM.2021.1282. Epub 2022 Feb 28.
    DOI PubMed: 35255603
  • Tanaka A, Mochizuki T, Ishibashi T, Akamizu T, Matsuoka TA, Nishi M.
    Reduced Fat Taste Sensitivity in Obese Japanese Patients and Its Recovery after a Short-Term Weight Loss Program.
    J Nutr Sci Vitaminol (Tokyo). 2022;68(6):504-512. doi: 10.3177/jnsv.68.504.
    DOI PubMed: 36596548

2021年

  • Takeshima K, Li Y, Kakudo K, Hirokawa M, Nishihara E, Shimatsu A, Takahashi Y, Akamizu T.
    Proposal of diagnostic criteria for IgG4-related thyroid disease
    Endocr J. 2021 Jan 28;68(1):1-6. doi: 10.1507/endocrj.EJ20-0557. Epub 2020 Dec 12.
    DOI PubMed: 33311000
  • Morita S, Inai Y, Minakata S, Kishimoto S, Manabe S, Iwahashi N, Ino K, Ito Y, Akamizu T, Ihara Y.
    Quantification of serum C-mannosyl tryptophan by novel assay to evaluate renal function and vascular complications in patients with type 2 diabetes
    Sci Rep. 2021 Jan 21;11(1):1946. doi: 10.1038/s41598-021-81479-y.
    DOI PubMed: 33479412

2020年

  • Uraki S, Furuta H, Miyawaki M, Matsutani N, Shima Y, Iwamoto M, Matsuno S, Morita S, Furuta M, Doi A, Iwakura H, Ariyasu H, Nishi M, Suzuki H, Akamizu T.
    Neonatal diabetes caused by the heterozygous Pro1198Leu mutation in the ABCC8 gene in a male infant: 6-year clinical course
    J Diabetes Investig. 2020 Mar;11(2):502-505. doi: 10.1111/jdi.13127. Epub 2019 Aug 27.
    DOI PubMed: 31390154
  • Matsutani N, Furuta H, Matsuno S, Oku Y, Morita S, Uraki S, Doi A, Furuta M, Iwakura H, Ariyasu H, Nishi M, Akamizu T.
    Identification of a compound heterozygous inactivating ABCC8 gene mutation responsible for young-onset diabetes with exome sequencing
    J Diabetes Investig. 2020 Mar;11(2):333-336. doi: 10.1111/jdi.13138. Epub 2019 Sep 19.
    DOI PubMed: 31479591
  • Karatojima M, Furuta H, Matsutani N, Matsuno S, Tamai M, Komiya K, Morita S, Uraki S, Doi A, Furuta M, Iwakura H, Ariyasu H, Nishi M, Akamizu T.
    A family in which people with a heterozygous ABCC8 gene mutation (p.Lys1385Gln) have progressed from hyperinsulinemic hypoglycemia to hyperglycemia
    J Diabetes. 2020 Jan;12(1):21-24. doi: 10.1111/1753-0407.12990. Epub 2019 Oct 21.
    DOI PubMed: 31578783
  • Takeuchi T, Ishigaki Y, Hirota Y, Hasegawa Y, Yorifuji T, Kadowaki H, Akamizu T, Ogawa W, Katagiri H.
    Clinical characteristics of insulin resistance syndromes: A nationwide survey in Japan
    J Diabetes Investig. 2020 May;11(3):603-616. doi: 10.1111/jdi.13171. Epub 2019 Dec 5.
    DOI PubMed: 31677333
  • Ishibashi T, Morita S, Kishimoto S, Uraki S, Takeshima K, Furukawa Y, Inaba H, Ariyasu H, Iwakura H, Furuta H, Nishi M, Papa FR, Akamizu T.
    Nicotinic acetylcholine receptor signaling regulates inositol-requiring enzyme 1α activation to protect β-cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress
    J Diabetes Investig. 2020 Jul;11(4):801-813. doi: 10.1111/jdi.13211. Epub 2020 Feb 17.
    DOI PubMed: 31925927
  • Takeshima K, Ariyasu H, Uraki S, Kitahara C, Morita S, Inaba H, Iwakura H, Warigaya K, Murata SI, Yamazaki Y, Sasano H, Akamizu T.
    Head and Neck Paraganglioma Atypically Carrying a Succinate Dehydrogenase Subunit B Mutation (L157X)
    Intern Med. 2020 May 1;59(9):1167-1171. doi: 10.2169/internalmedicine.3607-19. Epub 2020 Feb 5.
    DOI PubMed: 32023584
  • Takagi H, Iwama S, Sugimura Y, Takahashi Y, Oki Y, Akamizu T, Arima H.
    Diagnosis and treatment of autoimmune and IgG4-related hypophysitis: clinical guidelines of the Japan Endocrine Society
    Endocr J. 2020 Apr 28;67(4):373-378. doi: 10.1507/endocrj.EJ19-0569. Epub 2020 Mar 7.
    DOI PubMed: 32037390
  • Kurimoto C, Inaba H, Ariyasu H, Iwakura H, Ueda Y, Uraki S, Takeshima K, Furukawa Y, Morita S, Yamamoto Y, Yamashita S, Katsuda M, Hayata A, Akamatsu H, Jinnin M, Hara I, Yamaue H, Akamizu T.
    Predictive and sensitive biomarkers for thyroid dysfunctions during treatment with immune-checkpoint inhibitors
    Cancer Sci. 2020 May;111(5):1468-1477. doi: 10.1111/cas.14363. Epub 2020 Mar 17.
    DOI PubMed: 32086984
  • Inaba H, Ariyasu H, Iwakura H, Kurimoto C, Takeshima K, Morita S, Furuta H, Hotomi M, Akamizu T.
    Distinct clinical features and prognosis between persistent and temporary thyroid dysfunctions by immune-checkpoint inhibitors.
    Endocr J. 2021 Feb 28;68(2):231-241. doi: 10.1507/endocrj.EJ20-0371. Epub 2020 Oct 3.
    DOI PubMed: 33012745
  • Kaneto H, Obata A, Kimura T, Shimoda M, Kinoshita T, Matsuoka TA, Kaku K.
    Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class.
    Int J Mol Sci. 2021 Mar 17;22(6):3062. doi: 10.3390/ijms22063062.
    DOI PubMed: 33802741
  • Tanikawa K, Kaneko K, Abe S, Nakato J, Tokuyama Y, Odaka S, Iwakura H, Sato M, Kurabayashi A, Suzuki H, Makita M, Ikemoto H, Matsumura S, Inoue K, Ohinata K.
    Wheat-ghretropins: novel ghrelin-releasing peptides derived from wheat protein.
    FEBS Open Bio. 2021 Apr;11(4):1144-1152. doi: 10.1002/2211-5463.13124. Epub 2021 Mar 18.
    DOI PubMed: 33605550
  • Inaba H, Aizawa T.
    Coronavirus Disease 2019 and the Thyroid - Progress and Perspectives.
    Front Endocrinol (Lausanne). 2021 Jun 24;12:708333. doi: 10.3389/fendo.2021.708333.
    DOI PubMed: 34276567
  • Fukaishi T, Nakagawa Y, Fukunaka A, Sato T, Hara A, Nakao K, Saito M, Kohno K, Miyatsuka T, Tamaki M, Matsuhisa M, Matsuoka TA, Yamada T, Watada H, Fujitani Y.
    Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice.
    Diabetologia. 2021 Dec;64(12):2803-2816. doi: 10.1007/s00125-021-05560-x. Epub 2021 Sep 9.
    DOI PubMed: 34498099
  • Nishi N, Takeshima K, Morita S, Iwakura H, Nishi M, Matsuoka T.
    Deterioration of pituitary function without relapse after steroid therapy for IgG4-related hypophysitis.
    Endocrinol Diabetes Metab Case Rep. 2021 Jul 1;2021:21-0029. doi: 10.1530/EDM-21-0029. Epub ahead of print.
    DOI PubMed: 34236042
  • Nagai Y, Matsuoka TA, Shimo N, Miyatsuka T, Miyazaki S, Tashiro F, Miyazaki JI, Katakami N, Shimomura I.
    Glucotoxicity-induced suppression of Cox6a2 expression provokes β-cell dysfunction via augmented ROS production.
    Biochem Biophys Res Commun. 2021 Jun 4;556:134-141. doi: 10.1016/j.bbrc.2021.03.148. Epub 2021 Apr 8.
    DOI PubMed: 33839409
  • Kishimoto S, Sasaki H, Kurisu S, Ogawa K, Matsuno S, Furuta H, Arita M, Naka K, Nanjo K, Akamizu T.
    Bilateral atrophy of the extensor digitorum brevis muscle might be a useful sign for diagnosing diabetic polyneuropathy in Japanese men who do not sit in the traditional "seiza" style.
    J Diabetes Investig. 2021 Mar;12(3):398-408. doi: 10.1111/jdi.13367. Epub 2020 Aug 16.
    DOI PubMed: 33481342
  • Kosugi D, Inaba H, Kaido Y, Ito S, Hirobata T, Toyofuku M, Matsuoka T, Inoue G.
    Beneficial effects of sodium glucose cotransporter 2 inhibitors on left ventricular mass in patients with diabetes mellitus.
    J Diabetes. 2021 Nov;13(11):847-856. doi: 10.1111/1753-0407.13209. Epub 2021 Jul 21.
    DOI PubMed: 34231959